The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. The authors conclude that the originally high B12 levels were indicative of undiagnosed cancer (Arendt, 2019). In the same way, HCbl may also be a potential marker for cancer with poor prognosis, in partic- Cancer Epidemiol. Finding the true cause means ruling out or confirming each possibility – in other words, diagnosis. However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. J Natl Cancer Inst 2013;105:(23):1799-805. But did do vitamin IV's For years. To assess high Cbl levels and risk of cancer, Arendt and his colleagues used Danish Medical registries to review the records of 333,667 patients without cancer who had been referred for Cbl testing. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. vitamin B12 The information provided herein should not be used for diagnosis or treatment of any medical condition. Abnormal vitamin B12 levels can have various causes, ranging in severity from 'serious' to 'generally fatal'. TUESDAY, Aug. 22, 2017 (HealthDay News) -- Men, and especially male smokers, appear to be more likely to develop lung cancer if they take high doses of vitamins B6 and B12… Arendt JF, Farkas DK, Pedersen L, Nexo E, Sorensen HT. Paper III. HCbl in solid tumors is related to an excess synthesis of transcobalamins by the tumor or an increase in haptocorrin secondary to hyperleukocytosis [ 6 - 8 ]. A high level indicates a true B12 deficiency. Carcinomas most frequently involved are HCC and metastatic colon, breast and pancreatic cancer. Specifically, the researchers found that high vitamin D levels were linked with an increased risk of skin, prostate and blood cancers, and a decreased risk of lung cancer. Not surprisingly, a r … HCbl in solid tumors is related to an excess synthesis of transcobalamins by the tumor or an increase in haptocorrin secondary to hyperleukocytosis [6–8]. ... stomach cancer high red blood cell count... and more than 60 others. And, if you remember, reverse causation is when instead of X leading to Y, maybe Y is instead leading to X. 2016;40:158-165. Yet, Carmel et al. Vitamin B12 is part of the vitamin B complex and is essential for maintaining nerve function, fatty acid metabolism, and DNA and amino acid synthesis. By lowering homocysteine levels, it may also protect against cardiovascular disease. im taking 5000 mcg of b12 . Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. A large-scale study looked at 5,000 lung cancer-control pairs and reviewed genetic data of 29k cancer … Both venous thromboembolism (VTE) and high plasma vitamin B12 levels (cobalamin, Cbl) are markers of occult cancer and aggressive cancer with a poor p… Why is a vitamin B-12 level test useful? Hi Ashweb901 I read (or miss-read) it the other way round - having low levels of B12 and B9 may increase the risk of BC - but then I'm not a medically trained person. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. The lower levels of vitamin B12 in serum are often used to assess the state of the vitamin, but this approach generates a high rate of false-negative results. in 1977 reported a significant association between high serum vitamin B12 levels, or hypercobalaminemia (HCbl), and solid tumors. This article attempts to draw mortality conclusions from 10-year old single B12 level determinations without corrections for the often fatal diseases associated with high levels; high levels demand a careful work up, and should not be attributed to OTC supplementation. And indeed, nearly three-quarters of cancer patients exhibit elevated B12 levels. High levels of vitamin B12 in a person's blood are associated with an increased risk of early death, according to research published last month in the journal JAMA Network Open. I take no suppliments. In this population-based cohort study, we assessed VTE risk among cancer patients with high plasma Cbl levels. However, the implications for early cancer detection in primary care have not been assessed. A number of studies have shown that holotranscobalamin (the complex between transcobalamin II and vitamin B12) may be more reliable indicator of the status of vitamin B12 [ 14 ]. However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. Elevated plasma vitamin B12 levels and cancer prognosis: A population-based cohort study. Vitamin B supplementation can have side effects for human health, including cancer risk. INTRODUCTION: Both venous thromboembolism (VTE) and high plasma vitamin B12 levels (cobalamin, Cbl) are markers of occult cancer and aggressive cancer with a poor prognosis. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Some people who take suppliments go much higher ...very very high. The methylfolate is what converts serum blood b-12 to cellular usable b12. There are cases where an individual has an elevated vitamin B12 level that is seen as an incidental finding in someone who has not recently received a vitamin B12 injection or taken a vitamin B12 supplement. Read on to learn more about testing B-12 levels and what the test results mean. High B-12 levels may indicate liver disease, diabetes, or another condition. Background: A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. Background A substantial proportion of patients referred for plasma vitamin B12 (cobalamin [Cbl]) measurement present with high Cbl levels, which have been reported in patients with different cancer types. So, elevated B12 levels may just be a marker for cancer. since beginning this my serum level went from 500 to >2000, is the supplement the cause? A large Danish population study identified a correlation between high plasma B12 levels and elevated risk of hematological, smoking-related, and alcohol-related cancers ; and cancer patients with elevated B12 levels had higher mortality than those with normal values . Dr. Gurmukh Singh answered 49 years experience Pathology So, instead of high B12 blood levels leading to cancer, maybe cancer leads to high blood levels. According to the Mayo Clinic, "Vitamin B12, or cobalamin, helps nerve cells, red blood cells and is used in the creation of DNA." read high levels can be cancer!!! Vitamin B12 supplements will not cause elevated B12 blood levels 2. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Over-production of Vitamin B12 can be caused by cirrhosis, hepatitis, polycythemia vera or myelocytic leukemia. Vitamin B12 levels of at least 550 but less than 650 pg/mL are associated with a 26% increased mortality risk vs. levels below 400 pg/mL. However, it is extremely rare to have a high blood level from too much vitamin B12 in the diet. Chiche et al. Numerous other cancers have been associated with an increase in B12 levels, including types of breast, colon, and stomach ( Andres, 2013 ). Good luck VCL High vitamin B12 and cancer Association between elevated B12 and cancer first described in 1975 by Carmel et al. However, the cancer risk among patients with newly diagnosed high Cbl levels has not been adequately examined. Methods: We conducted this cohort study using population-based Danish … Now mine is getting lower in the 800's. My b12 was 1186. The vitamin b12 elevation can be influenced by supplements And foods And fortified cereals. Elevated Plasma Vitamin B12 Levels as a Marker for Cancer: A Population-based Cohort Study. tion between high serum vitamin B12 levels, or hyp-ercobalaminemia (HCbl), and solid tumors. Similarly, in over 476,000 people without cancer or vitamin B12 prescriptions (injections), high B12 levels (> 1,200 pmol/L) were linked to a higher incidence of cancer . We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. These also determine how well your detox system is working. And maybe stored in the liver that could raise levels. Vitamin B12 can be obtained through diet (including eggs, dairy products, poultry, meat, and fortified cereals) and in supplement form. "Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4‐Q1 = 1.29; 95% CI 1.02–1.62; Ptrend = 0.03).). I always have extremely high serum b12 so I just use a little less of my methylcobalamin b12 shots and add more methylfolate to boost the process into the cellular form. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 showed that 23% of patients with high B12 had a previously unknown solid cancer in They looked at circulating vitamin B12 (cobalamin) levels in around 25,000 subjects one year prior to a cancer diagnosis, and compared these with about 60,000 cancer patients for whom blood cobalamin hadn’t been measured. Moreover, in this study, the prevalence of vitamin B 12 deficiency among metastatic solid tumor cancer (except gastric) patients was 0.8% (4/527 patients), while 41.9% (221/527 patients) of the patients had high vitamin B 12 levels, which shows that, in particular, elevation of vitamin B 12 is frequently observed in metastatic cancer patients. 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